Job Details

Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Principal CADD Scientist to join our team, working directly with scientists in our state-of-the-art wetlab and with our distributed computational chemistry and CADD science teams across the US.

What You Will Do (Key Responsibilities)

• Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents.
• Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts.
• Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches.
• Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making.
• Adapt to a fast-paced environment where innovation and quick iteration are encouraged.

What you'll bring

• PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD.
• Deep understanding of structure-based drug design and protein-ligand interactions.
• Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.
• Minimum of 5+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs.
• Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too.

What we offer

• Competitive Pay
• Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)
• Stock Option Eligibility
• 401(k) Plan
• Open PTO Policy
• Paid Company Holidays
• Subsidized lunch and snacks at our offices

About Genesis Molecular AI

Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company's generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets.

Genesis is headquartered in San Mateo, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.