Job Details

Senior Associate Scientist II, Process Development - Downstream

Forge, a member of Ajinomoto Bio-Pharma Services, is a gene therapy development engine, focused on enabling access to life changing gene therapies and helping bring them from idea into reality. We partner with innovators in the gene therapy community: scientists, physicians, biotech/pharma companies, and patient groups. We bring expertise in gene therapy manufacturing and therapeutics development to the table, helping to champion teams that are navigating the long road from the lab bench to the bedside. Our goal is simple but vital to patients living with disease, and we take it seriously. With a patient-first approach, we are forging new models for working together to better accelerate these transformative medicines to reach those who need them the most.

Forge is based in Columbus, Ohio, in a 200,000 square foot facility known affectionately by team members as the Hearth. The Hearth is a custom-designed cGMP facility dedicated to AAV manufacturing and hosts scalable, end-to-end manufacturing services.

Responsibilities:

• Assist with overall maintenance of the production and testing facilities. This includes but may not be limited to performing quality systems checks, buffer preparation, autoclaving of media, packing of biohazard material, monitoring or sanitizing equipment, preparing facility for production campaigns, and periodic cleaning of incubators, centrifuges, FPLCs, biological safety cabinets (BSCs), and other equipment.
• Culturing cells, performing transfections and/or infections with seed vectors, harvesting and lysing cells, and purifying vectors using density gradients, FPLC, or other techniques.
• Provide support in the receipt and distribution of incoming raw materials for research, preclinical, and clinical manufacturing.
• Unpack reagents, maintaining proper cold storage, restock supplies in storerooms or laboratories.
• Quarantine and prepare incoming raw materials intended for preclinical or clinical manufacturing for inspection and release.
• Assist in maintaining proper inventories of raw materials and consumables.
• Prepares formulations and raw materials as specified in protocols without the introduction of contaminants.
• Prepare sterile reagents as dictated by procedures or management by filtration or steam autoclaving.
• Maintains clean work environment in all work areas.
• Reports any discrepancies from protocols/study procedures or any materials preparation problems to management.
• Delivering results in a high paced environment.
• Package and ship finished product to clients in accordance with procedures and regulations.

Qualifications:

• Bachelor's degree in Biology, Molecular Biology, Virology, Biochemistry or related discipline.
• Practical experience with FPLC is required, ideally with lab, pilot, and large-scale systems.
• Experience with other aspects of downstream purification (e.g. clarification/filtration, TFF, etc.).
• Experience with purification of vaccines or viral vectors is preferred.
• Experience with production of biologics and performing bioassays is preferred.
• Must be self-motivating, organized and proactive.
• Strong technical aptitude including demonstrated experience in applying scientific reasoning to solve complex problems.
• Ability to work hours necessary to support production and/or product transfer activities.
• Ability to work in loud noise environments and in Personal Protective Equipment (PPE) and cleanroom gowning attire as needed.

Physical Requirements:

This position works in both a laboratory environment and typical office environment where the physical work demands will vary depending on the specific tasks and duties required of the job. The employee will be stationary (standing/sitting) for extended periods of time. Employees regularly wear personal protective equipment based on the task being performed. Must be able to work in a confined space, such as a clean room or laboratory environment. Ability to identify small details within the field of vision, distinguish between different colors, and accurately identify objects within a specific area.

Life at Forge:

We are a team of diverse, driven and passionate people working together to trailblaze a new model for how we make medicines to treat patients with genetic diseases. Our team members use their creativity and talent to invent new solutions, meet new demands, and offer the most effective services in the industry. Forge's core values lay the foundation for H.O.P.E. It provides us a common purpose that we all understand, work towards and live by.

H

ARDWORKING - We work hard and smart, making a persistent and determined effort toward success. Working hard, with focus and desire is the key.

O

PEN - We strive to be approachable, actively listen and encourage others to contribute and speak up. We positively offer and receive constructive feedback.

P

URPOSE DRIVEN - We are passionate about working towards and delivering on our mission to manufacture gene therapies.

E

NGAGED - We are fully absorbed by and enthusiastic about our work and take positive action to further Forge's vision, mission and goals.

We've Got You Covered:

We take the health and happiness of our employees seriously and are consistently evaluating new ways to make our benefits truly FORGE ttable.

Health, Dental, and Vision insurance that starts on your first day at Forge, with 90% of premiums covered for team members as well as dependents.

Competitive paid time off plan.

Annual bonus for all full-time employees.

401(K) company match.

Fully-stocked kitchen with free food/drinks.

12 weeks of paid parental leave - additional discount programs include childcare support & dependent care.

Employee Assistance Program.

Wellness benefits (financial planning services, mental health counseling, employer paid disability).

Onsite fitness facility.

Professional & Personal development resources.